Biomedical -

Biomedical Treatment For Autism

Biomedical treatment for autism: Autism is a very complex and its incidence is rising worldwide and what was 1 in 1,000 a decade ago is now 1 in 54 according to the CDC (Central Disease Control USA).

Genetic problems cannot account for this more than 600% rise. The concept of autism being epigenetic is gaining ground.

genetic vulnerability in an individual that interacts with environmental factors leading to multileveled disturbances of the underlying biology.
Many biomedical abnormalities have been identified in autism and 85% to 100% of these children have signs of immune problems, oxidative stress, mitochondrial problems, and environmental toxins.

Sometimes one treatment shows great benefit, but it is more common that each treatment helps a small amount. However, the cumulative effect of multiple treatments can be substantial.

Younger children are the ones most likely to benefit, especially those who had a period of normal development followed by regression, but older children and adults can often benefit as well.

Poor detoxifying capacity

Poor detoxifying capacity

these children have defective methylation cycles. The cycle is a complex reaction that takes place in every cell and is an important process for adequate cell functioning. There are two parts to the cycle. First the transfer of methyl groups that help in turning genes on and off, development of neurotransmitters, building flexible cell membranes, etc. Second is the transsulfuration pathway of the cycle. This produces Glutathione which is a very important antioxidant and detoxifying agent. It helps rid the body of toxins, prevents oxidation (rusting) of cells, helps produce energy from mitochondria and helps in immune function and the breakdown of neurotransmitters. This very important cycle needs Vitamin B6, B12, Folate, and others for proper functioning.

Impact of inflammation

Impact of inflammation

Studies indicate an impact of inflammation on the cause and course of autism. Inflammation is the body’s way of fighting an attack. Ideally, when a “foreign” substance—a toxin, bacteria, or a virus—enters the body, a cascade of inflammatory chemicals and processes occur to fight off the invader. When the battle is over, an anti-inflammatory process begins and calms the body down again. In some people, this process of ramping up and cooling down does not go smoothly. Those people can become stuck in a constant state of inflammation that can damage the body. Offspring of mothers with inflammatory diseases like rheumatoid arthritis have a greater chance of autism. Similarly, ongoing inflammation can continue to damage the brains of children with autism and increase risk of seizures.

Mitochondrial dysfunction

Mitochondrial dysfunction

Mitochondria are tiny parts of almost every cell in your body. Mitochondria are like the powerhouse of the cells. They turn sugar and oxygen into energy that the cells need to work. In mitochondrial diseases, the mitochondria cannot efficiently turn sugar and oxygen into energy, so the cells do not work correctly. It appears that 5 to 20 percent of children with autism have mitochondrial dysfunction as the underlying cause of their symptoms. Children diagnosed with autism and have underlying mitochondrial dysfunction experience regression following a simple childhood illness (ear infection, common cold, etc.) or other cause of fever or inflammation. Regression refers to a loss of developmental skills such as language or motor abilities. It may be accompanied by other symptoms of mitochondrial disorder such as fatigue, gastrointestinal distress, seizures and/or motor delays.

Leaky gut

Leaky gut

Altered intestinal permeability was found in 43% of autistic patients, but not found in any of the controls (Harvard University). This is commonly referred to as “leaky gut”. It means that there are larger than normal spaces present between the cells of the gut wall. These allow undigested food and other toxins to enter the bloodstream. When incompletely broken down foods enter the body, the immune system mounts an attack against the “foreigner” resulting in food allergies and sensitivities. The release of antibodies triggers inflammatory reactions when these foods are eaten again. The chronic inflammation lowers IgA levels. Sufficient levels of IgA are needed to protect the intestinal tract from clostridia and yeast. The decreasing IgA levels allow for even further microbe proliferation in the intestinal tract. Vitamin and mineral deficiencies and abnormal or low normal gut flora as well as fungal infections can cause the leaky gut problem.

Metabolic problems

Metabolic problems

Metabolic conditions such as mitochondrial disease and dysfunction and abnormalities in cerebral folate metabolism may affect a substantial number of children with ASD, while other metabolic conditions that have been associated with ASD such as disorders of creatine, cholesterol, pyridoxine, biotin, carnitine, γ-aminobutyric acid, purine, pyrimidine, and amino acid metabolism and urea cycle disorders have also been associated with ASD without the prevalence clearly known. Interestingly, all of these metabolic conditions have been associated with epilepsy in children with ASD. The identification and treatment of these disorders could improve the underlying metabolic derangements and potentially improve behavior and seizure frequency and/or severity in these individuals.

Immune Dysregulation

Immune Dysregulation

Some children in autism have immune dysregulation that causes recurrent infections, chronic inflammation and autoimmune reactions. There are skewed immunoglobulin patterns with raised IGE and IGG4 and IGG2 with reduced IGA, IGM and other IGGs. There is also an imbalance between antibody mediated response (Th2), which is increased and cellular mediated response (Th1), which is reduced. This results in less protection against germs and increased allergies and autoimmune reactions.

Environmental Factors that interact with the underlying defects

Diet

Diet

Genes use food to repair and develop the cells and tissues. Vitamins and Minerals form important coenzymes for crucial reactions in the body. Children with autism have very poor eating patterns because of poor appetite, food fetish, sensory issues, reduced or faulty absorption and eating contaminated foods. Various nutritional deficiencies can cause effects like zinc deficiency that can cause poor appetite and eczema, iron deficiency that can cause restlessness and inattention.

Food allergies can cause leaky gut.

Casein and Gluten are long peptides that are not completely digested and thus form opiate like substances that fogs the brain

Toxins

Toxins

Many children with autism have challenged detoxification capacity. Thus heavy metals like mercury (found in dental fillings and seafood), plastics containing BPA and many environmental toxins are harmful and propagate the disease.

Oxidative Stress

Oxidative Stress

Oxygen is essential to life but produces harmful byproducts as it works in the body. These are free radicals called Reactive Oxygen Species or ROS which can damage the cells and are normally removed by antioxidants. Oxidative stress is caused by factors like air pollution, radiation, UV light, inflammation etc. With reduced formation of Glutathione (antioxidant) and reduced intake of external antioxidants like Vitamin C and Selenium children with autism suffer cellular and DNA damage.

Infections

Infections

In the presence of the immune dysregulation, infections can cause damage. Viruses in particular can cause neuroinflammation in the brain. Bacterial infections often are treated by antibiotics that damage the normal essential gut flora that are important in immune functioning, producing vitamins and preventing leaky gut.

EMF– Electromagnetic Fields from electronic gadgets like mobile phones and television

EMF– Electromagnetic Fields from electronic gadgets like mobile phones and television

Effects of EMF/RFR exposure affects nervous system electrical activity, and these in turn generate the set of behaviors seen in autism. These behaviors may emerge from alterations of electrophysiological oscillatory synchronization and EMF/RFR could contribute to these by de-tuning the organism. EMF/RFR effects can occur within minutes (Blank, 2009) and may, in part, explain clinical reports of ‘intermittent autism’ – for example, some children with mitochondrial disease who have ups and downs of their bioenergetics status ‘have autism’ on their bad days but don’t display autistic features on their good days. ADHD and sleep problems have also been linked to EMF. The American Academy of Paediatrics recommends that children below age 2 years should not be exposed to these gadgets.

Different Biomedical Treatments

The main philosophy of Biomedical treatment are the following:

Avoid what harms
casein, gluten, additives, soya, phenols
Give what heals
Antioxidant
Essential Fatty Acids
Immunotherapy
COLOSTRUM
IVIG
Hyperbaric oxygen
Treat Underlying problems
Detoxification
Chelation
Correcting Nutritional Deficiencies
Vitamins
Minerals
Omega Fatty Acids
Essential Amino Acids
Providing a good diet
Treating the gut
Treating the leaky gut
Treating dysbiosis that is the imbalance of normal gut flora
Digestive Enzymes
Treating constipation
Treating reflux and enterocolitis
Detoxification
Preventing oxidative stress
Supporting the Detoxification Pathway
Removing toxins
Removing EMFs
Treating immune dysregulation and inflammation
Immune system support
Removing Immune triggers
Breaking the inflammatory cycle

Biomedical Treatment For Autism

Poor detoxifying capacity

Impact of inflammation

Mitochondrial dysfunction

Leaky gut

Metabolic problems

Immune Dysregulation

Environmental Factors that interact with the underlying defects

Diet

Toxins

Oxidative Stress

Infections

EMF– Electromagnetic Fields from electronic gadgets like mobile phones and television

Different Biomedical Treatments

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